Electron microscopy, the first Centerwide shared resource, magnifies by 100,000 times the inner workings of a cell or virus. In this photo, electron microscopy specialists Steve MacFarlane and Judy Bousman examine fruit flies. (Photo by Dean Forbes) - Hutchinson Center: Gallery- powered by SmugMug

Led by Janell Baldwin, Shared Resources is one of the nation’s largest groups of core facilities to support research. Ranging from proteomics and scientific imaging to therapeutic manufacturing and genomics, the 45 or so different services provide centralized expertise and technologies. Like unseen beams supporting a building, Shared Resources is a major factor in the Center’s long record of scientific successes.

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Hutchinson Center > Electron microscopy, the first Centerwide shared resource, magnifies by 100,000 times the inner workings of a cell or virus. In this photo, electron microscopy specialists Steve MacFarlane and Judy Bousman examine fruit flies.
(Photo by Dean Forbes)

Hutchinson Center > Working from the basement of the Weintraub Building, LaToya McKenzie and other glassware technicians provide a steady supply of spotless beakers, pipettes, flasks and other glass or plastic lab items—an essential, if often invisible, service.
(Photo by Dean Forbes)

Hutchinson Center > The Therapeutic Manufacturing resource supports the development and manufacture of novel biological molecules and innovative cell-based therapies for Phase 1 and 2 clinical testing. These clean-room facilities permit the reproducible production of large-scale quantities of biological reagents and therapeutic cells under strict quality control and in compliance with regulatory requirements. Lyonel Shine (left) and Doug Woodle, biologics associates, are pictured in the Biologics Production Facility with chromatography equipment utilized in the purification of clinical monoclonal antibodies and fusion proteins.
(Photo by Dean Forbes)

Hutchinson Center > Lisa McLemore, a registered histotechnician in Experimental Histopathology, uses her 17 years of histology experience to expertly cut sections of paraffin-embedded tissue. Experimental Histopathology staff cut more than 26,000 tissue sections a year.
(Photo by Dean Forbes)

Hutchinson Center > Kara Breymeyer of Public Health Sciences Division’s Cancer Prevention Program Prevention Center staff serves a meal to nutrition study participant Stephanie Rosse.
(Photo by Clayton Hibbert)

Hutchinson Center > Dr. Jason Hogan, staff scientist, focuses on the workings of the LTQ-Orbitrap. Hogan uses the mass spectrometer to measure the masses of peptides created from an enzymatic digestion of a complex protein mixture. “We then fragment the measured peptides and use the masses of resulting fragment pieces to identify the peptide sequence and thus the protein from which it came,” Hogan said.
(Photo by Dean Forbes)

Hutchinson Center > Jenni Risler, genomics specialist, uses the Biomek FX robot to transfer a library of E. coli clones from wells of a 96-well plate into a single reservoir. Each clone carries a plasmid with a unique short hairpin RNA (shRNA) that is tagged with a barcode sequence for identification. The bacterial pools will be scaled-up to create large amounts of pooled shRNA plasmid that will be packaged in a lentiviral vector. RNA inhibition (RNAi) experiments may be performed on human or mouse cells using these lentiviral stocks.
(Photo by Dean Forbes)

Hutchinson Center > The Flow Cytometry resource offers a wide range of instrumentation, from single-laser benchtop analyzers to complex multi-laser cell sorts for cell analysis and sorting. Here, Weldon DeBusk, Flow Cytometry specialist, sets up a calcium flux experiment on the LSR-2.
(Photo by Philip Meadows)

Electron microscopy, the first Centerwide shared resource, magnifies by 100,000 times the inner workings of a cell or virus. In this photo, electron microscopy specialists Steve MacFarlane and Judy Bousman examine fruit flies.
(Photo by Dean Forbes)